ABSTRACT
ABSTRACT Objective: This study aimed to translate, and perform a cross-cultural adaptation, and validation of the Vancouver Symptom Score (VSS) for bladder and bowel dysfunction (BBD) for Brazilian children and adolescents Materials and Methods: Six steps were performed for the translation and cross-cultural adaptation: (1) translation, (2) synthesis of translations, (3) back-translation, (4) pre-final version of the translated instrument, (5) pilot test and degree of comprehensibility and (6) elaboration of the Brazilian version of the VSS. For validation, the Brazilian Dysfunctional Voiding Score (DVSS) questionnaire was used. Results: Validation was performed on a sample of 107 children and adolescents with a mean age of 9.2 ± 2.84 years, presenting BBD and 107 without BBD (control group-CG). There was a positive correlation (r = 0.91, 95% CI 0.88 to 0.93, p < 0.0001) between total VSS score and total DVSS score. VSS was higher in patients with BBD (p < 0.0001). The internal consistency estimated by Cronbach's alpha was 0.87 for patients with BBD. The VSS showed excellent diagnostic accuracy in detecting cases, with an area under the ROC curve of 98% (95% CI 0.96 to 0.99, p < 0.001). A cut-off value of >11 points produced a sensitivity of 100% (95% CI 96.4% to 100%) and a specificity of 91.8% (95% CI 85.1% to 95.6%). Conclusion: The translated, cross-culturally adapted, and validated VSS for the Brazilian population is a reliable and valid tool to identify symptoms of BBD in children and adolescents aged five to 16 years, whose first language is Brazilian Portuguese.
ABSTRACT
O traumatismo cardíaco penetrante constitui-se em evento que pode evoluir para o óbito rapidamente e por isso demanda diagnóstico e tratamento imediatos. Apesar da evolução dos métodos de imagem, às vezes não é possível identificá-lo de maneira não invasiva. Assim, o emprego da janela pericárdica constitui-se um método de fácil realização, com elevada sensibilidade e baixa morbidade, especialmente útil em pequenos centros com recursos escassos e limitados. (AU)
The penetrating cardiac trauma is into event that can lead to death quickly and therefore demands immediate diagnosis and treatment. Despite the evolution of the imaging methods, sometimes it is not possible to identify it using a non-invasive method. Thus, the use of pericardial window is an easy to accomplish method, wich has high sensibility and low morbity, specially useful in small centers with few and limited resourses. (AU)
Subject(s)
Humans , Pericardial Window Techniques , Myocardial Contusions/surgery , Myocardial Contusions/diagnosis , Thoracic Surgery, Video-Assisted , Pericardiocentesis , Diagnostic Techniques, SurgicalABSTRACT
A sindrome de Li-Fraumeni e uma sindrome de predisposicao familiar ao cancer, caracterizada pela...
Subject(s)
Humans , Female , Adult , Tumor Suppressor Protein p53 , Neoplasms, Multiple Primary/genetics , Li-Fraumeni Syndrome/genetics , Colorectal Neoplasms , Adenocarcinoma , Mutation/geneticsABSTRACT
A síndrome de Li-Fraumeni é uma síndrome de predisposiçäo familiar ao câncer, caracterizada pela presença de múltiplos tumores, tais como sarcomas, carcinomas de mama, tumores cerebrais e leucemia. O caso relatado é de uma paciente feminina de 37 anos, que apresenta uma significativa história familiar de câncer, bem como história pessoal de seis diferentes tumores primários (um de cólon, um nevus displásico, um de ovário e três de mama). O sequenciamento do gene supressor de tumor p53 em seus linfócitos presentes no sangue periférico revelou uma mutaçäo do aminoácido triptofano (TGG) para um códon de parada prematuro (TAG), no nucleotídeo 437 do códon 146 do éxon 5 deste gene. As implicaçöes clínicas, preventivas e éticas deste caso säo também abordadas.